Acute Bacterial Otitis Media due to H. Pharmacodynamics Thrombin is a highly specific protease that transforms the fibrinogen contained in Sealer Protein (Human) into fibrin. Ergotamine reduces extracranial blood flow, decreases the amplitude of pulsation in the cranial arteries, and decreases hyperperfusion of the territory of the basilar artery In the remaining pediatric patient, the AT product was administered as part of a separate research study.